The treatment of peri-implantitis is a significant challenge due to the various strategies proposed in the literature, involving different types of grafts and membranes in the regenerative surgical technique.

Purpose: The objective of this review is to describe the different regenerative surgical techniques currently used to treat peri-implant defects and their efficacy.

Materials and Methods: Literature in the Pubmed and Scopus databases was evaluated to rescue ECCAs that described regenerative surgical treatment for peri-implantitis. The inclusion criteria included patients with at least one osseointegrated implant affected by a pathological condition compatible with the definition of peri-implantitis, describing a clinical intervention aimed at regenerative surgical treatment of the condition, with a minimum follow-up period of 6 months. . The Cochrane Collaboration tool for risk of bias assessment was used and the synthesis of the results was done by means of a tabulation.

Results: A total of 11 RCTs were included, taking into account clinical and radiographic parameters to later evaluate the efficacy of regenerative surgical therapy for peri-implant bone defects.

Conclusion: It was shown that regenerative surgical therapies for the treatment of peri-implantitis were effective, achieving an improvement in clinical and radiographic parameters. Results were determined against the background of varying definitions of peri-implantitis and study heterogeneity. For future RCTs, it is necessary to unify the definition and the initial clinical and radiographic parameters of peri-implant disease to achieve homogeneity of the studies.