The aim of this article is to review the subject of myofacial pain syndrome (MPDS) in the literature and to highlight the etiology, diagnosis and the different approach for management. The author searched for the similar studies in the Google scholar, research gate and PubMed. The search depend on the study parameter using keywords like trigger points, mechanism of trigger point activation, diagnosis of myofacial pain and management of myofacial pain.Most data at literature reveal that myofacial pain syndrome (MPDS) is relatated to the myofacial trigger points (MTrPs). These myofacial trigger points (MTrPs) are mostly over all due to muscle overload and muscle disharmony which lead to increase at the peripheral and centeral sensitization. Management of myofacial pain syndrome (MPDS) is depending on identification of the etiological facters. It is drugs management, occlusal therapy and physical therapy. Drugs line include analgesic drugs like non steroidal anti inflammatory drugs (NSADs), muscle relaxants like Tizanidine, anticonvusants for example Gabapentine, tricyclic antidepressant. Occlusal therapy is either splint, or occlusal correction surgical and non surgical. Physical therapy of myofacial pain syndrome (MPDS) is very variable it includes many techniques like deep massage, muscle relaxation by heat or ultra sound, dry needling, laser therapy, biofeedback, EMG feedback, magnetic therapy and transculanous electric nerve stimulation (TENS).