Anaerobic digestion is a properly-mounted bioenergy system for methane recovery from natural feedstocks. Numerous municipal and agricultural wastes have been investigated underneath premier working situations in anaerobic digesters, albeit with a wide range of stated methane yields. this transformation is by and large attributed to the particular natural materials inside the handled waste, especially the Lipids (L), Carbohydrates (C), and proteins (P). Numerous papers have examined the effect of substrate composition at the performance of anaerobic digesters. This paper opinions the state-of the-art articles that evaluated the organic composition of substrates and their impact on the treatment efficiency and bio methane recovery of anaerobic digestion. The assessment demonstrates the top-quality C/N ratios for max methane yield, and discusses the basic four stages for predicting the theoretical methane manufacturing based on the basic and organic composition. Moreover, Optimizing the organic composition (LCP) of the wastes is essential for keeping the performance and balance of the anaerobic digestion manner.