Global Journal of Infectious Diseases
[ ISSN : 2992-9636 ]
Antiretroviral Therapy: A Compendium of the Evolving Treatment Paradigm for HIV infection
1Assistant Professor, Department of Internal Medicine, PGIMER, Chandigarh, India
2Junior Resident, Department of Internal Medicine, PGIMER, Chandigarh, India
3Junior Resident, Department of Community Medicine, LHMC, New Delhi, India
4Senior Resident, Department of Emergency Medicine, AIIMS, New Delhi, India
5Assistant Professor, Department of Pharmacology, PGIMER, Chandigarh, India
6Associate Professor, Department of Dermatology, Venereology and Leprology, PGIMER, Chandigarh,
India
7Professor and Head, Department of Emergency Medicine, AIIMS, New Delhi, India
Corresponding Authors
Keywords
Abstract
Guidelines on Antiretroviral Therapy (ART) are updated regularly and it is important to be abreast with the increasing knowledge. Recent international recommendation suggests initiating the ART to all those individuals who have detectable viremia. While it is imperative to perform baseline CD4+ counts, viral loads and resistance testing before starting treatment, non-availability of any of these tests should not delay treatment initiation. Currently, ART in the form of daily administered triple-drug combination therapy consisting of 2 NRTIs plus 1 INSTI/PI/NNRTI, is recommended for newly diagnosed patients. The regimen should be selected based on virological efficacy, adverse effects, drug-drug interactions and cost. This article is an attempt to give an overview of existing and upcoming antiretroviral drugs and recent recommendations in the management of people living with human immunodeficiency virus infection.