The middle third of the face is a wide region that is directly related to facial structure, for this reason it is a region frequently treated by professionals through cosmetic interventions. In this area there are several important structures that are correlated with each other, such as bones, ligaments, muscles, fat pads, and subcutaneous tissue. In order to properly treat the upper third of the face, it is important to know the characteristics of the products that will be used, since the interaction of the product with the anatomical area where it is injected directly interferes on the results obtained. The objective of this case series is to describe possible combinations of hyaluronic acid used in the middle third of the face to obtain natural aesthetic results. Three patients had the middle third of the face treated with an individualized treatment plan, combining different products according to the results objectives of each clinical case. The clinical cases illustrated and discussed in this case series demonstrate that the combination of hyaluronic acid-based products, the knowledge of the properties and differentials of each product, as well as the use of appropriate techniques, are favorable strategies to achieve natural results in the third face medium.