Vaccination is the most economical and effective means to prevent control and even eliminate infectious diseases, and it is one of the most basic public health service items provided by the government to the masses. Every year, April 25th is the Publicity Day for Children’s Vaccination in China. Due to the new crown pneumonia, the city is closed to fight the epidemic, and the vaccination is suspended. My country’s rapid control of the new crown epidemic has started in an orderly manner with child vaccinations. In the 70 years since the founding of New China, my country’s public health, especially the prevention and control of infectious diseases, has made world-renowned achievements, which are inseparable from vaccination. This article aims to carry out the vaccination work under the prevention and control of the epidemic situation in my country, the types of domestic Class I and II vaccines and the vaccination procedures, as well as the methods for replanting children after they are not vaccinated in time due to the epidemic or other uncontrollable factors. Vaccine research and application development of innovative vaccines are summarized and sorted out.