Psychology problem like depressed is always associated with physical problem in the era of SARS COV-2 pandemic. Many problems have arisen in this situation at this moment. The purpose of this narrative review is to provide an important overview of effective interventions in reducing depression to make it easier for doctors, nurses, and other health professionals to plan appropriate interventions to overcome and reduce depression in the general population based on evidence-based practice. The research method is carried out by conducting a quality research exploration on the research database via pubmed.gov. The types of articles selected were limited to articles published during 2020 and those related to depression due to the Covid-19 pandemic. The results showed that out of 35 articles obtained using the keyword “effective intervention for depression during pandemic covid-19”, there were 3 (three) articles that were relevant to the purpose of this review. Regular exercise activities and togetherness with family in carrying out daily activities accompanied by clean and healthy living behaviors can reduce depression and maintain a lower level of depression during the Pandemic of Covid-19.