The main objective of the current study was to investigate the direct and indirect influences of attachment dimensions on self-management, being mediated by the doctor-patient relationship. To meet this objective, a quantitative study with correlational research design via path analysis multiple regression was utilized to establish statistical associations between the core variables. The participants of the study consisted of 90 male and 90 female chronic patients who suffered from cardiovascular disease, chronic respiratory disease, and diabetes in Yangon, Myanmar. Three sets of questionnaires were employed: Burmese translated version of Revised Adult Attachment Scale (RAAS) to test close, depend and anxiety attachment dimension, Partners in Health (PIH) scale to measure self-management and Patient-Doctor Depth of Relationship (PDDR) to test the doctor-patient relationship. The results revealed the following major findings: i. Close attachment dimension had a significant direct effect on self-management; ii. Depend and anxiety attachment dimensions did not have a significant direct effect on self-management; iii. Close attachment dimension has a significant indirect effect on self-management, being mediated by doctor-patient relationship; iv. Depend and anxiety attachment dimension did not have a significant indirect effect on self-management, being mediated by doctor-patient relationship