A large part of the world population is affected by some temporomandibular joint disorder (TMD). The challenges in the treatment of these disorders start from its proper diagnosis, which is often done inappropriately, to the choice of therapy. The highest prevalence is in cases of temporomandibular disorder of muscular origin. The symptoms resulting from TMD are usually accentuated in periods of greater emotional stress. With the Sars-CoV-2 (Covid-19) pandemic, many patients lost family members, jobs and their own income, and neurological disorders, linked to anxiety and sleep disorders, increased the occurrence of symptoms connected to TMD. Conservative treatment should be the first choice to combat TMD, when all these alternatives are exhausted, surgical treatment can be planned, according to the patient’s pathology. Generally, the treatment of choice is the use of drugs, but a large number of alternatives have emerged and some have shown to be very promising. This review seeks to talk a little about drug treatment for the relief of TMD symptoms.