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Concepts in Neurology and Research
[ ISSN : 2833-3667 ]


Exercise Benefits for Progressive Supranuclear Palsy: A Narrative Review

Review Article
Volume 5 - Issue 1 | Article DOI :  10.54026/CNR/1018


Honey MRF1, Brigden OJ2, Paventi MG2, Pressman-Cyna KB2 and Kragulj L1

1School of Kinesiology, University of British Columbia, Vancouver, Canada
2Faculty of Medicine and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada

Corresponding Authors

Maximillian Honey, School of Kinesiology,5955 University Boulevard, University of British Columbia, Vancouver, Canada, V6T 1Z1

Keywords

Progressive Supranuclear Palsy; Exercise Therapy; Physiotherapy; Rehabilitation; Neurodegenerative Disorders

Received : February 06, 2026
Published : February 20, 2026

Abstract

Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of 4R-tau protein aggregates in the cortex, brainstem and basal ganglia. The clinical ramifications are variable but often include a combination of vertical gaze palsy, axial rigidity, cognitive impairment and postural instability leading to frequent falls. Currently, PSP has no cure, and available pharmacological treatments offer limited benefit. Exercise-based therapy has emerged as a promising supportive approach for managing the functional decline in PSP. This narrative review summarizes the current evidence regarding the benefits of exercise interventions for individuals with PSP. A literature search was conducted using different medical databases to identify studies examining physiotherapy, rehabilitation, and structured exercise programs in PSP. The f indings suggest that exercise interventions targeting balance, gait, and strength may improve motor performance, reduce fall risk, and enhance quality of life. However, evidence remains limited by small sample sizes, differing methodologies, and short follow-up. Despite these limitations, exercise appears to be a safe and valuable adjunct therapy for patients. Further research is needed to establish standardized exercise protocols and determine long-term outcomes.