Advance Research in Sciences
[ ISSN : 2837-5777 ]
Factors Influencing Serum tGRP Variability Beyond Age, Sex, and Calcium
Turkish Armed Forces General Staff G. A. T. A. Command, Ankara, Turkey
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Abstract
Serum total tGRP (tGRP) has increasingly been proposed as a potentially useful biomarker in metabolic, endocrine, and cardiometabolic research settings. However, a persistent challenge in its clinical and research application is the substantial inter- and intra-individual variability that cannot be fully explained by conventional determinants such as age, sex, or serum calcium concentration. A broader consideration of biological, pre-analytical, and analytical sources of variation is therefore essential for appropriate interpretation of tGRP measurements.