Aim. To evaluate the frequency of periodontal disease and its relationship with age and the presence of metabolic syndrome in a group of patients from Sierra Gorda, Mexico. Methodology. A descriptive, cross-sectional and prospective study was carried out in 208 patients between 20 and 79 years of age, both sexes. Prior to the epidemiological survey, a Dentist Surgeon was calibrated (Kappa=0.91; p=001). To measure the presence of periodontal disease (PD), the Community Periodontal Index (IPC) was collected. To measure the association between the study variables, the Likelihood Ratio values were calculated because in all cases some of the observed values were ≤ 5, considering a confidence level of 95%. Results. Diabetes and Dyslipidemia were the two comorbidities that occurred most frequently, observing that the older, the higher the probability of finding subjects with some type of comorbidity (p=0.001). In patients who presented comorbidities, a higher frequency of moderate to severe gingivitis and mild periodontitis and cases of moderate to severe periodontitis were observed. Conclusions. It is confirmed how aging and comorbidities are factors of greatest impact on the deterioration of dental support tissues and structures, which leads to greater vulnerability to PD and its complications.