Background: Traditional cognitive-behavioral models often fail to address long-term, treatment-resistant psychosomatic disorders rooted in the enteric nervous system. Second Brain Psychology (SBP) proposes a diagnostic and therapeutic framework for addressing these deep-seated blockages by decoding the Innate Emotional Matrix.

Methods: This study presents a clinical case series of nine patients — including military officers, high-level professionals, and entrepreneurs — presenting with treatment- resistant panic disorder, agoraphobia, and chronic anxiety. The operational protocol consists of a five-session diagnostic check-up followed by the ESYDET program, which employs over 100 argumentative modules and 50 adaptive sequences to facilitate the biochemical “digestion” of accumulated life stressors.

Results: Across all cases, patients reported significant functional recovery, with symptom reduction from an initial VAS score of 10/10 to full remission. Among the most notable outcomes were the extinction of avoidance behaviors, sustained for up to 10 years, and the complete restoration of territorial autonomy.

Conclusion: The SBP model and the ESYDET protocol demonstrate significant potential in resolving chronic distress where conventional therapies have failed, by acting on enteric-emotional memory and restoring autonomic homeostasis. Further controlled studies are required for full empirical validation of the method.