Current Research in Psychology and Behavioral Science
[ ISSN : 2833-0986 ]

Hypomania with Low-Dose Lamotrigine Suggests it Really is an Antidepressant

Case Report
Volume 5 - Issue 1 | Article DOI : 10.54026/CRPBS/10110

Alexis-Daniel Vigneault1* and Howard C Margolese1,2

1Department of Psychiatry, McGill University, Canada
2Prevention and Early Intervention Program for Psychoses, McGill University Health Centre, Canada

Corresponding Authors

Alexis-Daniel Vigneault, Department of Psychiatry, McGill University, Allan Memorial Institute, 1025 Pine Ave W, Montreal, Quebec H3A 1A1, Canada


Bipolar disorder; Hypomania; Anticonvulsant; Lamotrigine; Adverse effect

Received : April 03, 2024
Published : April 29, 2024


Depression predominates over any other mood phases in bipolar I disorder, and treatment options remain sparse. Lamotrigine, an anticonvulsant used for the prevention and treatment of bipolar depression, has been reported to induce hypomanic and manic switches. Its multimodal mechanism of action may provide an explanation for its propensity to induce mood switches. The authors report a case of hypomania developing briefly after the introduction of very low-dose adjunctive lamotrigine for the treatment of bipolar depression and review proposed mechanisms of action.