As a result of a high density and consequences of periodontal recessions, this study aims to compare the effect of different types of platelet concentrates used to treat hard and soft oral tissue defects. For the purpose of methodology, clinical trials which treat the peri-implant and periodontal defects with platelet concentrates, compared with conventional treatments were searched in PubMed/Medline, EMBASE, Cochrane Oral Health Group, and Lilacs. No statistical differences were found in the main outcomes for the analyzed variables: probing depth, clinical attachment level, root coverage, coronal advance flap, keratinized gingival width. There were only found significant differences in the access flap variable, solely and related with platelet concentrates. To sum up, seems to be beneficial for the treatment of periodontal and peri-implant defects the utilization of platelet rich pplasma (PRP), platelet rich fibrin (PRF) and leucocyte platelet rich fibrin (L-PRF). Nevertheless, in order to analyze the biological behavior of this blood products it is imperative to perform further investigations of this subject.