Amyloid Gallbladder as an Initial Presentation of Multiple Myeloma (MM): A Rare Presentation November 22, 2021


Madhuri Chengappa* and Thejaswi K Poonacha

We present a rare case of Amyloid (AL) deposition in the gallbladder as an initial presentation of MM. The patient was a 92-year-old female who was admitted to the hospital with right upper quadrant pain. Computed Tomography (CT) abdomen and pelvis showed stone in the distal common bile duct and mildly distended gallbladder with wall thickening, she underwent ERCP for stone extraction followed by cholecystectomy. A postoperative histological examination revealed congo red stain positive for amyloidosis, positive apple-green birefringence under polarized light, and was typed as AL. Further workup, showed a lytic bone lesion on the skeletal survey and bone marrow core biopsy showed hypercellular bone marrow with increased plasma cells confirming the diagnosis of MM

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