Most soils under arid conditions have extremely low quality due to poor physical conditions, low organic matter and water retention capacity, soil fertility and consequently both low water and fertilizer use efficiencies. The present study was planned to investigate the effects of irrigation interval (II), irrigation methods (IM) and nitrogen fertilizer rates (NF) on wheat performance (yield and its components) and water use efficiency. The experiment was conducted at National Institute of Desert Studies Research Farm for two consecutive winter seasons of (2020/21) and (2021/22) in a sandy soil of North Sudan. The experiment design was complete randomized block in factorial arrangement with four replications. Factor (A) was irrigation methods with two types (furrow and basin), factor (B) was irrigation interval with three rates (7, 10, 13 days) and factor (c) was assigned to nitrogen with three rates (43, 86 and 129 Kg/fed). The results showed that irrigation methods had not significant p (≤.05) effect on wheat yield and its components and water use efficiency, irrigation interval affected significantly p (≤.05) on plant height, biomass, spike per meter square, grain yield and water use efficiency in both seasons Nitrogen fertilizer were effective highly significant p (≤.05) in improving biomass p (≤.05) and significantly p (≤.05) effect on plant height, number of spike per meter square, grain yield and water use efficiency in both seasons. Both irrigation interval and nitrogen fertilizer rates were not significant p (≤.05) effect on plant per meter. Maximum yield and high water use efficiency were obtained when irrigated every 7 days and added nitrogen fertilizer in rate of 129 Kg per fedan.