Prohexadione calcium affects peanut (Arachis hypogaea L.) vegetative growth and improves row visibility and efficiency of digging pods and inverting vines. While cultivar response to this plant growth regulator in peanut has been reported in the peer-reviewed literature, information on the impact of digging date and fungicide program for late leaf spot disease [Nothopassalora personata (Berk. & M.A. Curtis) U. Braun, C. Nakash., Videira & Crous] in presence of prohexadione calcium is limited. To address this limitation, research was conducted at two locations in 2018 with two levels of prohexadione calcium (0 or 2 applications at 140 g ai/ha), two levels of cultivar (Bailey and Sullivan), three levels of fungicide regimen (no fungicide, two sprays early in the cropping cycle when the pathogen for leaf spot disease was active, and five sprays throughout the time when the pathogen for this disease was active), and two levels of digging pods and inverting vines (optimum pod maturity or 10 days after optimum pod maturity). Prohexadione calcium increased row visibility of both cultivars regardless of other treatment factors, and row visibility of Sullivan was greater than Bailey in absence of prohexadione calcium. Canopy defoliation in presence of late leaf spot disease at optimum pod maturity was affected by prohexadione calcium but not at 10 days after optimum maturity. Greater canopy defoliation at optimum pod maturity and lower peanut yield were observed when prohexadione calcium was applied. These results suggest that a more compact plant following prohexadione calcium may create a microenvironment that supports late leaf spot disease. However, additional research is needed to support or refute these findings.