Sesame (Sesamum indicum) is an important oil seed crop containing more than 50% quality oil and a good source of protein in the world. Its economic production is governed by its management practices. To find the optimum dose of NPK fertilizer in the sandy loam soils under arid conditions, two-year field experiment was carried out during Kharif season 2021 and 2022 at Adaptive Research Farm (ARF), Karor Zone, Layyah Punjab Pakistan. Five treatments of NPK were used to optimize the NPK for Sesame cultivar TH-6 with three replications. Results showed that the maximum grain yield 765.3 kg ha-1 was recorded in 2021 as compared to 738.6 kg ha-1 in 2022 at ARF, where N113P113K60 (113 kg Urea ,113 kg P2 O5 ,60 kg ha-1 K2 O) was applied. Minimum yield and yield components were produced where NPK were not applied. It was concluded that the application of NPK at the rate of could improve yield and yield components of sesame in the agro-climatic conditions of Karor, Layyah.