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Corpus Journal of Case Reports
[ ISSN : 2833-4388 ]

Neonatal Intravenous Immunoglobulin (IVIG) Treatment for Chronic Anemia Due to Congenital Parvovirus Infection: A Case Report

Case Report
Volume 1 - Issue 1 | Article DOI : 10.54026/CJCR/1002

Olivia Janssen DO*, Jing Lin

1Department of Pediatrics, Icahn School of Medicine at Mount Sinai, USA
2Department of Counseling Education, University of Maryland, USA

Corresponding Authors

Olivia Janssen, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Icahn School of Medicine at Mount Sinai, New York, USA

Keywords

Parvovirus B19, Hydrops fetalis, Pure red blood cell aplasia, Intravenous immunoglobulin

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Received : June 05, 2020
Published : June 14, 2020

Abstract

Congenital Parvovirus B19 infection is a rare but serious condition that can result in hydrops fetalis and fetal death. Due to the virus’ cytotoxic effect on fetal red blood cell precursors, postnatal infection can cause a neonatal viremia and secondary pure red cell aplasia. Here, we describe a case of congenital parvovirus infection in a preterm infant complicated by hydrops fetalis and chronic anemia that responded to postnatal treatment with intravenous immunoglobulin (IVIG) administered on day of life 44. After treatment, the anemia resolved as the neonate exhibited interval increases in hemoglobin, hematocrit, and reticulocyte count with no subsequent need for red blood cell transfusions.