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Photobiomodulation Associated with Beta Tricalcium Phosphate Graft to Improve Initial Bone Healing December 27, 2021

ABSTRACT

Roberta Gava Pratti, Avacir Casanova Andrello, Dari de Oliveira Toginho Filho, Wilson Trevisan JĂșnior and Solange De Paula Ramos*

Aim: Beta Tricalcium Phosphate (βTCP) is a synthetic bone substitute with osteoconductive properties, however, it is quickly reabsorbed, which can result in a smaller volume of newly formed bone. Light-emitting diode (LED) therapy has osteoinductive and anti-inflammatory properties, accelerates healing, and may improve the clinical performance of βTCP grafts. The work evaluated the effect of LED therapy (630 nm, 4J/cm2 ) on βTCP grafts in the initial bone repair of bone defects in rat calvaria. Methods: Forty-two male Wistar rats were randomly divided into two groups: Control and LED groups. In each animal, two perforations were made in the skull (4.3 mm diameter), one filled with βTCP (TCP) and the other with a blood clot (Co). Seven animals from each group were euthanized on the 7th, 14th, and 30th days and the samples were submitted to histological and microtomographic analysis. Results: The Co-LED and TCP-LED defects presented increased defect areas and no inflammatory reaction after 7 days. After 14 days increased areas of primary bone were observed in the TCP and TCP-LED groups. After 30 days, TCP-LED defects presented reduced area and no foreign body reaction. Conclusion: Phototherapy associated with βTCP accelerated the initial bone repair process compared to the isolated use of βTCP

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