Aim: Beta Tricalcium Phosphate (βTCP) is a synthetic bone substitute with osteoconductive properties, however, it is quickly reabsorbed, which can result in a smaller volume of newly formed bone. Light-emitting diode (LED) therapy has osteoinductive and anti-inflammatory properties, accelerates healing, and may improve the clinical performance of βTCP grafts. The work evaluated the effect of LED therapy (630 nm, 4J/cm2 ) on βTCP grafts in the initial bone repair of bone defects in rat calvaria. Methods: Forty-two male Wistar rats were randomly divided into two groups: Control and LED groups. In each animal, two perforations were made in the skull (4.3 mm diameter), one filled with βTCP (TCP) and the other with a blood clot (Co). Seven animals from each group were euthanized on the 7th, 14th, and 30th days and the samples were submitted to histological and microtomographic analysis. Results: The Co-LED and TCP-LED defects presented increased defect areas and no inflammatory reaction after 7 days. After 14 days increased areas of primary bone were observed in the TCP and TCP-LED groups. After 30 days, TCP-LED defects presented reduced area and no foreign body reaction. Conclusion: Phototherapy associated with βTCP accelerated the initial bone repair process compared to the isolated use of βTCP