Global Journal of Pediatrics
[ ISSN : 2833-3721 ]
Research Progress on the Effect of Vitamin D on the Pathogenesis of Kawasaki Disease and the Prediction of Coronary Artery Lesion
1Children’s hospital of Shaanxi Provincial People’s Hospital Xi’an, China
2Xi’an Medical College Xi’an, Shaanxi, China
3Dept of pediatrics, the First people’s Hospital of Xianyang, China
4Beijing Children’s hospital, Affiliated to Capital Medical University, China
5Xi’an Institute of Innovation, Yan’an University, Xi’an, China
6Hospital with the Scientific-clinical Center of Cardiology, Ashgabat city, Turkmenistan
Corresponding Authors
Keywords
Abstract
Kawasaki Disease (KD), also known as mucocutaneous lymph node syndrome, is a kind of fever rash pediatric disease with systemic vasculitis as the main lesion. Its pathogenesis is not yet completely clear, the main pathological changes is systemic vasculitis, involving the small and medium-sized blood vessels of the body, especially coronary artery lesions are more obvious, can lead to coronary artery aneurysm, even serious sudden death. Because the disease can appear serious cardiovascular complications, has gradually attracted attention, in recent years, its incidence has gradually increased trend, has become one of the common pediatric acquired heart disease etiology. Vitamin D acts on the VDR in various tissues and cells of the human body. Many studies have shown that vitamin D not only participates in the traditional calcium and phosphorus metabolism, but also participates in immune regulation through a variety of mechanisms.