Determining compatibility of pesticides is important in developing effective management practices and adjusting to outbreaks of pests in cotton (Gossypium hirsutism L.). Field experiments were conducted in 2013 and 2014 to determine the effect of chloroacetamide herbicides with residual activity only and acephate with foliar activity against thrips (Frankliniella spp.) on control of emerged weeds by glyphosate, glufosinate, and a mixture of these herbicides. The residual herbicides acetochlor and S-metolachlor as well as the insecticide acephate did not affect control of emerged common ragweed (Ambrosia artemisiifolia L.) and Palmer amaranth (Amaranthus palmeri Watts.). Results from these trials indicate that weed control will not be compromised with co-application of glufosinate, glyphosate, and glufosinate plus glyphosate with acetochlor or S-metolachlor applied alone or with acephate.