Recently, several difficulties have been faced in the biomedical field, which prompted scientists to explore a wide variety of nanomaterials that can be used to solve issues using tissue regeneration strategies. For decades, Titanium, steel, and metals have been explored for the fabrication of medical implants due to their excellent properties such as hardness, strength, and biocompatibility, but these materials have limitations. Several reports have documented the increase in the human body rejecting Titanium, resulting in revision surgery [1]. Therefore, there is a need to develop materials that can be highly biocompatible, nontoxic, and biodegradable, leading to the development and use of nanomaterials. Additional Halloysite Clay Nanotubes (HNTs) have shown several properties that meet and exceed those needed to replace Titanium, steel, and Metals. This paper reviews the advances and prospects of the biomedical application of HNTs.